Rei Sekiguchi

I am a dentist-scientist and board-certified periodontist whose research integrates oral biology with computational approaches to investigate wound healing, salivary gland development, and tissue regeneration. I aim to define molecular and cellular mechanisms that inform translational strategies to restore oral and craniofacial tissues and improve patient care.

I conducted my PhD research through the National Institutes of Health (NIH) Graduate Partnerships Program in Kenneth Yamada’s laboratory at the NIH, where I also completed postdoctoral training and received an NIH K99/R00 Pathway to Independence Award.

BSc, University of Toronto

DDS, University of Toronto

MSc and Certificate in Periodontics, University of Rochester

PhD, Oral and Craniofacial Sciences and Biomedical and Health Informatics, University of Missouri-Kansas City (NIH Graduate Partnerships Program)

Sekiguchi R., Martin D., Yamada K. M., Single-cell RNA sequencing reveals genes relevant to periodontal therapy and periodontitis. *Physiol Genomics*. 2025;57(12):720–733.

Sekiguchi R., Martin D., Doyle A. D., Wang S., Yamada K. M., Salivary gland tissue recombination can modify cell fate. *J Dent Res*. 2024;103(7):755–764.

Sekiguchi R., Mehlferber M. M., Matsumoto K,. Wang S., Efficient gene knockout in salivary gland epithelial explant cultures. *J Dent Res*. 2023;102(2):197–206.

Sekiguchi R., Martin D., Yamada K. M., Single-cell RNA-seq identifies cell diversity in embryonic salivary glands. *J Dent Res*. 2020;99(1):69–78.

Sekiguchi R., Yamada K. M., Basement membranes in development and disease. *Curr Top Dev Biol*. 2018;130:143–191.