Kabilan Velliyagounder

My research focuses on the antimicrobial effect of human lactoferrin against various oral microbes. My team has successfully established experimentally induced periodontal disease, dental caries and oral candidiasis and systemic infections caused by Aggregatibacter actinomycetemcomitans, Streptococcus mutans and Candida albicans respectively in a mouse model. In addition, my ongoing research explores determining the effect of iron deficiency anemia in oral diseases. The results of my work will contribute to the understanding the role of IDA in oral diseases and provide novel approaches to prevention of these diseases. In addition, he is focusing on how iron deficiency anemia can alter oral and fecal microbiome. I’ve also successfully identified a naturally occurring group of organosulfur compounds with a significant potential to be used as an alternative therapy to treat oral and systemic diseases.

BS in Botany from PSG College of Arts and Science, Bharathiar University

MS, in Botany, Kongu Nadu Arts and Science, Bharathiar University,

MA in philosophy, Botany from Bharathiar University.

1. A novel approach for anti-candida drug development.
2. The Effect of Iron Deficiency Anemia on Experimental Dental Caries
3. Iron deficiency anemia and oral Microbiome
4. The microflora diversity in dental plaque biofilms on brackets of orthodontic patient

1. Velliyagounder K, Rozario SD, Fine DH. The effects of human lactoferrin in experimentally induced systemic candidiasis. J Med Microbiol. 2019 Nov 8. doi: 10.1099/jmm.0.001098. PMID: 31702539.
2. Kabilan Velliyagounder Shobika Ponnambalam, Krupa Chavan, Kenneth Markowitz. 2019. Oral manifestations and association with oral diseases of iron deficiency anemia-a literature-based review. Journal of the Formosan Medical Association (accepted).
3. Dania Bahdila, Kenneth Markowitz, Siddhi Pawar, Krupa Chavan, Daniel H Fine, Kabilan Velliyagounder. 2019. The effect of iron deficiency anemia on experimental dental caries in mice. Archives of Oral Biology. 105:13-19.
4. Velliyagounder K, Anil Ardeshna, Julia Koo, Mathew Rhee, Daniel H. Fine. 2019. The microflora diversity and profiles in dental plaque biofilms on brackets and tooth surfaces of orthodontic patients. Journal of Indian Orthodontic Society: 1-6. doi:10.1177/0301574 219851160.
5. Velliyagounder K, Bahdila D, Pawar S, Fine DH. Role of lactoferrin and lactoferrin-derived peptides in oral and maxillofacial diseases. Oral Dis. 2018 25(3): 652-669 doi: 10.1111 /odi.12868.
6. Velliyagounder K, and Mariam Aldajani 2017. Anti-candidal activities of lactoferrin in systemic candidiasis Book edited NOVA Scientific Publication, NY.
7. Velusamy, SK., K. Markowitz., H. Fine and K. Velliyagounder. 2016. Human lactoferrin protects against Streptococcus mutans-induced caries in mice. Oral Diseases. 22: 148-154. doi:10.1111/odi.12401.
8. Alabdulmohsen, W., K. Markowitz, DH. Fine and K. Velliyagounder 2015. Diabetic Lactoferrin Deficient Mice Demonstrate greater susceptibility to Experimental Periodontal Disease J Oral Biology 2(2): 1-6.
9. Velliyagounder K, Alsaedi W, Alabdulmohsen W, Markowitz K, Fine DH. 2014. Oral lactoferrin protects against experimental candidiasis in mice. J Appl Microbiol. 2015 Jan;118(1):212-21.
10. Senthil Kumar Velusamy, Daniel H. Fine, Kabilan Velliyagounder. 2014. Prophylactic effect of human lactoferrin against Streptococcus mutans bacteremia in lactoferrin knockout mice.16(9): 762–767.
11. Velusamy, SK., R. Poojary, R. Ardeshna, Alabdulmohsen, D. H. Fine and K. Velliyagounder 2014. Protective Effects of Human lactoferrin during Aggregatibacter actinomycetemcomitans-induced bacteremia in lactoferrin-deficient mice. Antimicrob. Agents Chemother. 2014, 58(1):397.
12. Fine DH, G. Toruner, K. Velliyagounder, V. Sampathkumar, D. Godboley and D. Furgang. 2013. A lactotransferrin single nucleotide polymorphism demonstrates biological activity that can reduce susceptibility to caries. Infection and Immunity 81(5): 1596-605.
13. Velliyagounder. 2013. Lactoferrin Knockout Mice Demonstrates Greater Susceptibility to Aggregatibacter actinomycetemcomitans-Induced Periodontal Disease. Journal of Periodontology 84(11):1690-1701.
14. Krishnaraj, G., Velliyagounder, K, Furgang D, Daniel Fine. Human salivary Cystatin SA. 2012. Exhibits Antimicrobial Effect Against A. actinomycetemcomitans. Journal of Periodontal Research 47:661-673.
15. Velliyagounder, K, G. Krishnaraj, V. Senthil kumar, and Daniel Fine. (2012). In vitro efficacy of diallyl sulfides against the periodontopathogen Aggregatibacter actinomycetemcomitans. Antimicrobial Agents and Chemotherapy 56(5): 2397-2407.