My research focuses on how to translate molecular mechanisms of bone modeling and remodeling into applicable clinical models for accelerated orthodontics. Using animal models of orthodontic tooth movement, I investigate the effect of multiple molecular pathways on the rate of tooth movement. My clinical research interests include how to tackle challenging conditions such as tooth ankylosis and posterior open bite through new treatment modalities and the study of possible genetic etiology. In addition, I also lead projects on dental device technology innovation.


DMD, MA, Peking University, School of Stomatology

MA, Indiana University

PhD, Harvard University

Research Projects

  • Animal models and clinical applications of accelerated orthodontics through bone modeling and bone remodeling
  • Clinical studies and treatment of ankylosis
  • 3D printing in orthodontics
  • Clinical and genetic studies of posterior open bite
  • Dental device innovation and technology


  1. Ko J, Bloomstein RD, Briss D, Holland JN, Morsy HM, Kasper FK, Huang W. Effect of build angle and layer height on the accuracy of 3-dimensional printed dental models. American Journal of Orthodontics and Dentofacial Orthopedics. 2021 (In press)
  2. Huang W, Shan B, Ang BS, Ko J, Bloomstein RD, Cangialosi TJ. Review of etiology of posterior open bite: is there a possible genetic cause? Clinical, Cosmetic and Investigational Dentistry. 2020 Jun 25:12:233-240
  3. Huang W, Li Q, Amiry-Moghaddam M, Hokama M, Sardi SH, Nagao M, Warman ML, Olsen BR. Critical endothelial regulation by LRP5 during retinal vascular development. PLoS One. 2016 Mar 31;11(3)
  4. Huang W, Olsen BR. Skeletal defects in Osterix-Cre transgenic mice. Transgenic Research. 2015 Feb;24(1):167-72
  5. Sitara D, Razzaque MS, St-Arnaud R, Huang W, Taguchi T, Erben RG, Lanske B. Genetic ablation of vitamin D activation pathway reverses biochemical and skeletal anomalies in Fgf-23-null animals. The American Journal of Pathology. 2006 Dec;169(6):2161-70.
  6. Xu TM, Liu Y, Yang MZ, Huang W. Comparison of extraction versus nonextraction orthodontic treatment outcomes for borderline Chinese patients. American Journal of Orthodontics and Dentofacial Orthopedics. 2006 May;129(5):672-7.