Emi Shimizu

My research focuses on the molecular and physiological mechanisms regulating tertiary dentin formation from dental pulp cells, as well as pulp regeneration technology using induced pluripotent stem cells (iPSC) and oral stem cells. Through my work, I have identified how IGF1-ephrinB1 axis plays an important role in tertiary dentin formation and tooth formation using genetic mouse models. I have been awarded $2 million from the National Institutes of Health for her research, in addition to funding from Colgate-Palmolive to work on a method of finding a method for replicating the human oral environment in vitro, which could replace animal studies for periodontitis drugs.

PhD, Department of Endodontics, Graduate School of Nihon University

Certificate for Advanced Education Programs, Department of Endodontics, New York University College of Dentistry

1. Moreira MA, Moreira MM, Lomonaco D, Cáceres E, Witek L, Coelho  PG, Shimizu E, Quispe-Salcedo A, Feitosa VP, Effects on dentin nanomechanical properties, cell viability and dentin wettability of a novel plant-derived biomodification monomer, Dental Materials, 2024, PMID: 39068089

2. Yamauchi Y, Shimizu E, Duncan HF, Dynamic alterations in acetylation and modulation of histone deacetylase expression evident in the dentine–pulp complex during dentinogenesis, International Journal of Molecular Sciences, 25:6569, PMID: 38928274

3. Griffith A, Chande C, Kulkarni S, Morel J, Cheng Y-H, Shimizu E, Cugini C, Basuray S, Vivek K, Point-of-care diagnostic devices for periodontitis– current trends and urgent need, Sensors and Diagnostics, 3:1119-1134, 2024, PMID: 39007012

4. Duncan HF, Kobayashi Y, Yamauchi Y, Shimizu E, The reparative function of MMP13 in tertiary reactionary dentinogenesis after tooth injury, International Journal of Molecular Sciences, 25:875, 2024, PMID: 38255947

5. Duncan HF, Kobayashi Y, Kearney M, Shimizu E, Epigenetic therapeutics in dental pulp treatment: Hopes, challenges and concerns for the development of next-generation biomaterials, Bioactive materials. 27: 574-593, 2023, PMID: 37213443

6. Grgic O, Prijatelj V, Vucic S, Dhamo B, Trajanoska K, Monnereau C, Zrimsek M, Gautvik KM, Reppe S, Dudakovic A, Shimzu E, Haworth S, Timpson NJ, Jaddoe VWV, Jarvelin MR, Evans D, Uitterlinden AG, van Wijnen AJ, Ongkosuwito EM, Medina-Gomez C, Rivadeneira F, Wolvius EB, Novel Genetic Determinants of Dental Maturation in Children, Journal of Dental Research, 102:349-356, 2023, PMID: 36437532.

7. Griffith A, Mateen A, Markowitz K, Singer S, Cugini C, Shimizu E, Wiedman G, Kumar V, Alternative Antibiotics in Dentistry: Antimicrobial Peptides, Pharmaceutics, 14:1679, 2022, PMID: 36015305

8. Duncan HF, Kobayashi Y, Yamauchi Y, Quispe- Salcedo A, Feng ZC, Huang J, Partridge NC, Nakatani T, D'Armiento J, Shimizu E. The critical role of MMP13 in regulating tooth development and reactionary dentinogenesis repair through the Wnt signaling pathway, Frontiers in Cell and Developmental Biology, 2022, PMID: 35531096

9. Kaur B, Kobayashi Y, Cugini C, Shimizu E, A mini review: The potential biomarkers for non-invasive diagnosis of pulpal inflammation, Frontiers in Dental Medicine, Frontiers in Dental Medicine, published December 2021 (#equal contribution), doi.org/10.3389/fdmed.2021.718445

10. Gonzalez Marrero Y, Kobayashi Y, Falcon C, Falcon PA, Hirschberg CS, Shimizu E, Altered prevalence of pulp diagnoses in diabetes mellitus patients: A retrospective study, Journal of Endodontics, 48: 208-212, 2022, PMID: 34780805

11. Siddiqui Z, Acevedo-Jake AM, Griffith A, Kadincesme N, Dabek K, Hindi D, Kim KK, Kobayashi Y, Shimizu E, Kumar V. Cells and material-based strategies for regenerative endodontics, Bioactive Materials, 14: 234-249, 2021, PMID: 35310358

12. Kobayashi Y, Nouet J, Baljinnyam E, Siddiqui Z, Fine DH, Fraidenraich D, Kumar V, Shimizu E, iPSC-derived cranial neural crest-like cells can replicate dental pulp tissue with the aid of angiogenic hydrogel, Bioactive Materials, 14: 290-301, 2021, PMID: 35310357

13. Kobayashi Y, Quispe-Salcedo A, Bodas S, Matsumura S, Li E, Johnson R, Choudhury M, Fine DH, Nadimpalli S, Duncan HF, Dudakovic A, van Wijnen AJ, Shimizu E. Enamel hyper-mineralization caused by Ezh2 knockout in mesenchymal cells, Biochemical and Biophysical Research Communications, 567: 72-78, 2021, PMID: 34144503

14. Ye Y, Salvo E, Romero-Reyes M, Akerman S, Shimizu E, Kobayashi Y, Michot B, Gibbs J. Glia and orofacial pain: progress and future directions, International Journal of Molecular Sciences, 22: 5345, 2021, PMID: 34069553

15. Siddiqui Z, Kim K, Kadincesme N, Paul R, Kumar A, Kobayashi Y, Roy A, Choudhury M, Sarkar B, Yang J, Shimizu E, Kumar V. Angiogenic hydrogels for in situ tissue revascularization. Acta Biomaterialia. 126: 109-118, 2021, PMID: 33689817

16. Dixit1 M, Liu Z, Poudel S-B, Yildirim G, Zhang Y, Mehta S, Murik O, Altarescu G, Kobayashi Y, Shimizu E, Schaffler MB, Yakar S. Skeletal response to insulin in the naturally occurring type 1 diabetes mellitus mouse model. JBMR Plus, 5:e10483, 2021, PMID: 33977201

17. Yamauchi Y, Cooper PR, Shimizu E, Kobayashi Y, Smith AJ, Duncan HF. Mini-Review: Histone acetylation as a regenerative target in the dentine-pulp complex. Frontiers in Genetics, 2020, PMID: 32117431