Emi Shimizu

My research focuses on the molecular and physiological mechanisms regulating tertiary dentin formation from dental pulp cells, as well as pulp regeneration technology using induced pluripotent stem cells (iPSC) and oral stem cells. Through my work, I have identified how IGF1-ephrinB1 axis plays an important role in tertiary dentin formation and tooth formation using genetic mouse models. I have been awarded $2 million from the National Institutes of Health for her research, in addition to funding from Colgate-Palmolive to work on a method of finding a method for replicating the human oral environment in vitro, which could replace animal studies for periodontitis drugs.

PhD, Department of Endodontics, Graduate School of Nihon University

Certificate for Advanced Education Programs, Department of Endodontics, New York University College of Dentistry

1. Shimizu E, Tamasi J, Partridge NC. Alendronate affects osteoblast functions by crosstalk through ephrinB1-EphB. Journal of Dental Research. 91(3):268-274, 2012.
2. Shimizu E, Jong G, Partridge NC, Rosenberg PA, Lin LM. Histologic observation of a human immature permanent tooth with irreversible pulpitis after revascularization/regeneration procedure. Journal of Endodontics. 38(9):1293-1297, 2012.
3. Barnes VM, Xu T, Shimizu E, Nakatani T, Jefcoat S, Vasilov A, Qin L, Partridge NC. Triclosan blocks mmp13 expression in hormone-stimulated osteoblasts. Journal of Periodontology. 84(11):1683-1689, 2013.
4. Tamasi JA, Vasilov A, Shimizu E, Benton N, Johnson J, Bitel CL, Morrison N, Partridge NC. Monocyte chemoattractant protein-1 is a medicator of the anabolic action of parathyroid hormone on bone. Journal of Bone and Mineral Research. 28(9):1975-1986, 2013.
5. Shimizu E, Riccuci D, Albert J, Adel S Alobaid, Gibbs JL, , Huang G, Lin LM, Clinical, radiographic and histological observation of a human immature permanent tooth with apical periodontitis after revitalization treatment. Journal of Endodontics. 39(8):1078-1083, 2013.
6. Wang X, Jong G, Lin LM, Shimizu E. EphB/ephrinB interaction controls odontogenic/osteogenic differentiation with calcium hydroxide. Journal of Endodontics. 39(10):1256-1260, 2013.
7. Lin LM, Shimizu E, Gibbs JL, Loghin S, Ricucci D. Histologic and histobacteriologic observations of failed revascularization/revitalization therapy: a case report. Journal of Endodontics. 40(2):291-295, 2014.
8. Shimizu E, Nakatani T, He Z, Partridge NC. Parathyroid Hormone Regulates HDAC4 through PKA-mediated phosphorylation and dephosphorylation in osteoblastic cells. Journal of Biological Chemistry. 289(31):21340-21350, 2014.
9. Fei Y, Shimizu E, Nakatani T, McBurney MW, Partridge NC. Sirtuin 1 is a negative regulator of PTH stimulation of Matrix Metalloproteinase 13 in osteoblastic cells. Journal of Biological Chemistry. 290(13):8373-8382, 2015.
10. Duncan HF, Smith AJ, Garry J P, Fleming GJ, Partridge NC, Shimizu E, Gary P Moran GP, Cooper PR, The histone-deacetylase-inhibitor suberoylanilide hydroxamic acid promotes dental pulp repair mechanisms through modulation of matrix metalloproteinase-13 activity, Journal of Cellular Physiology. 231(4):798-816, 2016.
11. Matsumura S#, Quispe-Salcedo A#, Schiller CM, Shin JS, Locke BM, Yakar S, Shimizu E. IGF-1 signaling mediates activation of ephrinB1 in regulating tertiary dentin formation, Journal of Dental Research. 96(10):1153-1161, 2017. (#equal contribution)
12. Nguyen PK, Gao W, Patel SD, Weiner S, Shimizu E, Sarkar B, Kumar VA. Self-Assembling Peptide Hydrogel Targeting Dental Pulp Regeneration, ACS Omega, 3: 5980-5987, 2018.
13. Duncan HF, Kobayashi Y, Shimizu E. Growth factors and cell homing in dental tissue regeneration. Current Oral Health Reports, 5: 276-285, 2018.
14. Yamauchi Y, Cooper PR, Shimizu E, Kobayashi Y, Smith AJ, Duncan HF. Mini-Review: Histone acetylation as a regenerative target in the dentine-pulp complex. Front Genet. 2020 11: 1, PMID: 32117431