Center for Oral Infectious Diseases
Vincent K. Tsiagbe, M.S., Ph.D.
Associate Professor, Department of Oral Biology and Department of Pathology.
Graduate Education: M.S. (1981); Ph.D. (1986), University of Wisconsin, Madison WI.
PostDoctoral Training: New York University School of Medicine 1986-1993Other Activities : President and Founding Member of the Board of Trustees of The Association of African Biomedical Scientists, Inc., http://www.aabs-inc.org. (1998-present).
Our laboratory studies the intricate host-lymphoma relationships that govern the growth of germinal center-derived B-cell lymphomas. We have focused attention on an SJL mouse model for follicular center B-cell lymphomas (RCS) and have shown that the growth of these lymphomas depends on cytokine products (notably IL-2, -4, and -5) of host CD4 + T cells. IL-1 and IFN-? are required for optimum growth of the lymphoma cells. The production of these cytokines is ensured by presentation of MHC Class II antigen on the lymphoma cells, in conjunction with a lymphoma-encoded antigen, to CD4 + T cells bearing a particular T-cell receptor (V?16 +). This skewed recognition is the hallmark of a superantigen response; and the tumor's dependence on the host for growth is described as "reversed immunological surveillance." We have also shown that the tumor-associated antigen which mediates the superantigen response is encoded by a novel endogenous mouse mammary tumor virus (Mtv) gene (Mtv-29). We sequenced the Mtv and showed that the stimulating moiety resides within the ORF of the 3' Mtv-LTR, in effect serving as an indirect oncogen. The superantigen encoded by Mtv-29 is called vSAg29. We have employed micro-array gene profile analysis to uncover "lymphoma-specific" genes involved in the lymphoma process, as well as the biological pathways involved in lymphomagenesis.
We are also interested in human, germinal center-derived human B-cell lymphomas, that resemble mouse RCS, and contain CD4 T cells. Such lymphomas include Diffuse Large B Cell Lymphomas, and Burkitt's lymphomas. Considering that the human genome is laden with endogenous retroviral genes (HERVs), HERV proteins can potentially serve as "superantigen" for host T cells, and thus enhance lymphomagenesis. We are interested in the expression of such proteins in a human cancer. Another aspect of our research involves the role of the adaptive immune system in the development of periodontal diseases, using a rate model for periodontal disease.
Tsiagbe, V.K., and Fine, D.H, 2012. The Impact of Bacteria-Induced Adaptive Immune Responses in Periodontal Disease. In: Periodontal Diseases - A Clinician's Guide, ISBN 978-953-307-818-2. Ed. Jane Manakil. InTech, pages 93-106.
Li Y, Messina C, Bendaoud M, Fine DH, Schreiner H, Tsiagbe VK, 2010. Adaptive immune response in osteoclastic bone resorption induced by orally administered Aggregatibacter actinomycetemcomitans in a rat model of periodontal disease. Mol Oral Microbiol. 25:275-292.
Scaglione BJ, Salerno E, Gala K, Pan M, Langer JA, Mostowski HS, Bauer S, Marti G, Li Y, Tsiagbe VK, Raveche ES, 2009. Regulatory T cells as central regulators of both autoimmunity and B cell malignancy in New Zealand Black mice. J. Autoimmun. 32:14-23.
Murano M, Xiong X, Murano N, Salzer JL, Lafaille JJ, Tsiagbe VK. Latent TGF-beta1-transduced CD4+ T cells suppress the progression of allergic encephalomyelitis. J Leukoc Biol. 2006;79:140-146.
Thomas RM, Haleem K, Siddique AB, Simmons WJ, Tsiagbe VK. Regulation of META env initiated Mtv29 superantigen (vSAg29) transcripts in SJL/J mice lymphomas: role of Ikaros, demethylation, and chromatin structural change in the transcriptional activation of vSAg29. J. Immunol. 2003;170:218-227.
Li, H, Ma X, Moskovits, T, Inghirami G., and Tsiagbe VK.. Identification of oligoclonal CD4 T cells in diffuse large B cell lymphomas. Clin Immunol. 2003;107:160-169.
Tsiagbe VK, Ponzio NM, Erianne GS, Zhang DJ, Thorbecke GJ, Inghirami G. Germinal center derived lymphomas, in: The biology of germinal centers in lymphoid tissue. Eds. G. J., Thorbecke, and V. K. Tsiagbe, Springer-Verlag, New York, NY, 1998; pg. 199-234.
Tsiagbe VK; Yoshimoto T; Asakawa J; Cho SY; Meruelo D; Thorbecke GJ ."Linkage of superantigen-like stimulation of syngeneic T cells in a mouse model of follicular center B cell lymphoma to transcription of endogenous mammary tumor virus".EMBO journal.1993;12:2313.
Monday, August 7, 2006