Center for Oral Infectious Diseases

Vijay Parashar, Ph.D.

Emi Shimizu , Ph.D.
Assistant Professor
Phone:
Fax     :
E-mail : shimize1@sdm.rutgers.edu

Oral Biology Department
Rutgers, The State University of New Jersey
185 South Orange Ave
MSB C-638
Newark, NJ 07103

Introduction:

Dr. Emi Shimizu is an Assistant Professor in the Department of Oral Biology. She received her D.D.S in Biology in 1998 from the Nihon University School of Dentistry at Matsudo in Japan. A Ph.D. in Endodontics from the Graduate School of Nihon University was received in 2002. She also enrolled Advanced Education Programs in Endodontics in New York University College of Dentistry and finished in 2012. Dr. Shimizu worked as an Assistant Professor in Department of Basic Science and Craniofacial Biology in New York University College of Dentistry and identified interaction of ephrin-Eph plays an important role in tertiary dentin formation using various mouse models. In December 2016, she joined the Department of Oral Biology at Rutgers School Dental Medicine.

Research Summary:

The dental pulp nourishes dentin, serves as a biosensor, contains a dental pulp stem cell population, and plays significant roles in tooth viability. Currently, the most common strategy to treat injured dental pulp (due to caries, restorative procedures, or trauma) is its removal, and substitution by synthetic materials. Indeed, advancements in dental research have increased our abilities to maintain pulpless teeth for prolonged periods of time. Nonetheless, pulpless teeth, without nutrition supply, innervation, and vascularization, becomes vulnerable to injury, lose the ability to sense environmental changes, and increase the risk for caries progression. In cases of improper endodontic restoration the teeth are more vulnerable to masticatory forces, may fracture, and have to be removed. Therefore, it is widely accepted that maintaining a vital pulp has many benefits. A healthy pulp is not only important for tooth viability, but for maintaining the capacity to generate tertiary dentin matrix beneath an injury. Dr. Shimizu laboratory is studying the physiological mechanisms regulating tertiary dentin following tooth injury using several mouse models.

List of publications

  • Duncan HF, Smith AJ, Garry J P, Fleming GJ, Partridge NC, Shimizu E, Gary P Moran GP, Cooper PR, The histone-deacetylase-inhibitor suberoylanilide hydroxamic acid promotes dental pulp repair mechanisms through modulation of matrix metalloproteinase-13 activity, Journal of Cellular Physiology. 231(4):798-816, 2016.
  • Fei Y, Shimizu E, Nakatani T, McBurney MW, Partridge NC. Sirtuin 1 is a negative regulator of PTH stimulation of Matrix Metalloproteinase 13 in osteoblastic cells. Journal of Biological Chemistry. 290(13):8373-8382, 2015.
  • Shimizu E, Nakatani T, He Z, Partridge NC. Parathyroid Hormone Regulates HDAC4 through PKA-mediated phosphorylation and dephosphorylation in osteoblastic cells. Journal of Biological Chemistry. 289(31):21340-21350, 2014.
  • Lin LM, Shimizu E, Gibbs JL, Loghin S, Ricucci D. Histologic and histobacteriologic observations of failed revascularization/revitalization therapy: a case report. Journal of Endodontics. 40(2):291-295, 2014.
  • Wang X, Jong G, Lin LM, Shimizu E. EphB/ephrinB interaction controls odontogenic/osteogenic differentiation with calcium hydroxide. Journal of Endodontics. 39(10):1256-1260, 2013.
  • Shimizu E, Riccuci D, Albert J, Adel S Alobaid, Gibbs JL, , Huang G, Lin LM, Clinical, radiographic and histological observation of a human immature permanent tooth with apical periodontitis after revitalization treatment. Journal of Endodontics. 39(8):1078-1083, 2013.
  • Tamasi JA, Vasilov A, Shimizu E, Benton N, Johnson J, Bitel CL, Morrison N, Partridge NC. Monocyte chemoattractant protein-1 is a medicator of the anabolic action of parathyroid hormone on bone. Journal of Bone and Mineral Research. 28(9):1975-1986, 2013.
  • Barnes VM, Xu T, Shimizu E, Nakatani T, Jefcoat S, Vasilov A, Qin L, Partridge NC. Triclosan blocks mmp13 expression in hormone-stimulated osteoblasts. Journal of Periodontology. 84(11):1683-1689, 2013.
  • Shimizu E, Jong G, Partridge NC, Rosenberg PA, Lin LM. Histologic observation of a human immature permanent tooth with irreversible pulpitis after revascularization/regeneration procedure. Journal of Endodontics. 38(9):1293-1297, 2012.
  • Shimizu E, Tamasi J, Partridge NC. Alendronate affects osteoblast functions by crosstalk through ephrinB1-EphB. Journal of Dental Research. 91(3):268-274, 2012.
  • Zhu J, Shimizu E, Zhang X, Partridge NC, Qin L. EGFR signaling suppresses osteoblast differentiation and inhibits expression of master osteoblastic transcription factors Runx2 and Osterix. Journal of Cellular Biochemistry. 112(7):1749-1760, 2011.
  • Boumah CE, Lee M, Selvamurugan N, Shimizu E, Partridge NC. Runx2 recruits p300 to mediate parathyroid hormone’s effects on histone acetylation and transcriptional activation of the matrix metalloproteinase-13 gene. Molecular Endocrinology. 23(8):1255-1263, 2009.
  • Shimizu E, Selvamurugan N, Westendorf JJ, Olson EN, Partridge NC. HDAC4 represses matrix metalloprotenase-13 transcription in osteoblastic cells and parathyroid hormone controls this repression. Journal of Biological Chemistry. 285(13):9616-9626, 2010.
  • Selvamurugan N, Shimizu E, Partridge NC. Identification and characterization of runx2 phosphorylation sites involved in matrix metalloproteinase-13 promoter activation. FEBS letters. 583(7):1141-1146, 2009.
  • Raggatt LJ, Qin L, Tamasi J, Jefcoat SCJr, Liew FY, Bevelock L, Shimizu E, Selvamurugan N, Feyen JHM, Partridge NC. IL-18 is regulated by parathyroid hormone and is required for its bone-anabolic actions. Journal of Biological Chemistry. 283(11):6790-6798, 2008.
  • Shimizu E, Selvamurugan N, Westendorf JJ, Partridge NC. Parathyroid hormone regulates histone deacetylases in osteoblasts. Annals of the New York Academy of Sciences. 1116:349-353, 2007.
  • Shimizu E, Nakayama Y, Nakajima Y, Kato N, Takai H, Kim DS, Arai M, Saito R, Sodek J, Ogata Y. Fibroblast growth factor 2 and cyclic AMP synergistically regulate bone sialoprotein gene expression. Bone. 39(1):42-52, 2006.