Center for Oral Infectious Diseases
Helen Schreiner, Ph.D.
I am currently Assistant Professor in the Department of Oral Biology. I received my BA degree from Barnard College in 1973. I did my graduate work in Dr. David Figurski's lab in the Department of Microbiology at Columbia University, studying the broad host range plasmid RK2 and received my Ph.D in1988. I came to the RBHS Center for Oral Infectious Diseases in 1994 after working at the Columbia University School of Dental and Oral Surgery. I currently teach Oral Biology to Dental students and post graduate dental specialty students. I also help coordinate the Dental Masters program and mentor students in the program.
My primary research interests include the identification of virulence genes from Actinobacillus actinomycetemcomitans (Aa) such as cytoleththal distending toxin (cdt). I have developed a periodontal disease model in rats to be used for in vivo assessment of bacterial virulence genes. I am also using this model to assess the susceptibility of different rat strains to Aa induced bone loss in order to identify host susceptibility genes. I have received RBHS Foundation grants in 2004 and 2005.
Schreiner, H, Sinatra K., Kaplan J.,Furgang, D., Kachlany S., Planet, P.
Perez, B. and Fine, D. 2003. Tight-Adherence genes of Actinobacillus
actinomycetemcomitans are required for virulence in a rat model.
Kaplan, J., Schreiner,H., Furgang, D. Fine, D. 2002. Population structure andGenetic Diversity of Actinobacillus actinomycetemcomitans Strains Isolated from localized Juvenile Periodontitis Patients. Journal of Clinical Microbiology 40:1181-1187.
Fine, D., Goncharoff, P., Schreiner, H., Chang, K., Furgang, D.,Figurski, D. 2001. Colonization and persistence of rough and smooth colony variants of Actinobacillus actinomycetemcomitans in the mouths of rats. Archives of oral Biology 46:1065-1078.
Fine, D. Furgang, D., Schreiner, H., Charlesworth, J., Ghazwan, G., Fitzgerald-Bocarsly, Figurski, D. 1999. Phenotypic variation in Actinobacillus actinomycetemcomitans during laboratory growth: implications for virulence. Microbiology 145:1335-134.
Wednesday, April 2, 2008