Center for Oral Infectious Diseases
Dr. Vijay Parashar is an Assistant Professor in the Department of Oral Biology. He received his Bachelor of Science from Panjab University in India in 1999 and a Master of Science from the Thapar University two years later. A Ph.D. in Molecular Biology from the Panjab University followed in 2006. From 2006 through 2007 Dr. Parashar was a Postdoctoral Fellow at the Wayne State University in Detroit, MI. From 2007 through 2013 Dr. Parashar was a Research Associate at the New Jersey Medical School at Rutgers University, NJ. In 2014, he joined the faculty of Oral Biology Department in the School of Dental Medicine at Rutgers University.
Dr. Parashar's research program utilizes a combination of X-ray crystallography, biochemistry, molecular biology, computational chemistry and bacterial genetics techniques to study structure-function relationships of fundamentally important and broadly conserved proteins in oral bacteria. For latest updates, access Parashar laboratory website by clicking here.
List of publications
- Underbayev C, Kasar S, Ruezinsky W, Degheidy H, Schneider JS, Marti G, Bauer S, Fraidenraich D, Parashar V, Raveche E & Batish M. (2016) Role of mir-15a/16-1 in early B cell development in a mouse model of chronic lymphocytic leukemia: the quest for the cell of origin. Oncotarget. 2016 DOI: 10.18632/oncotarget.11290.
- Parashar V, Aggarwal C, Federle MJ, Neiditch MB. Rgg protein structure-function and inhibition by cyclic peptide compounds. Proc Natl Acad Sci USA. 2015 Apr; 9(8): 499-506.
- Wilson R, Kumar P, Parashar V, Vilchèze C, Veyron-Churlet R, Freundlich JS, Barnes SW, Walker JR, Marchiano, Shenai S, Colangeli R, Jacobs WR, Neiditch MB, Kremer L, Alland D. (2013) Highly efficient antituberculosis activity of a new class of thiophene compounds which target the Mycobacterium tuberculosis Polyketide Synthase Pks13 and inhibit mycolic acid production. Nat Chem Biol. 2013 Aug;9(8):499-506. doi: 10.1038/nchembio.1277
- Parashar V, Konkol MP, Kearns DB, Neiditch MB. (2013) A Plasmid-Encoded Phosphatase Regulates Bacillus subtilis Biofilm Architecture, Sporulation, and Genetic Competence. J Bacteriol.195(10):2437-48.
- Parashar V, Jeffrey PD, Neiditch MB (2013) Conformational change-induced repeat domain expansion regulates Rap phosphatase quorum-sensing signal receptors. PLoS Biol. 11(3): e1001512. doi:10.1371/journal.pbio.1001512
- Sambanthamoorthy K, Sloup RE, Parashar V, Smith JM, Kim EE, Semmelhack MF, Neiditch MB, Waters CM. (2012) Identification of small molecules that antagonize diguanylate cyclase enzymes to inhibit biofilm formation. Antimicrob Agents Chemother. 56(10):5202-11.
- Mirouze N, Parashar V, Baker MD, Dubnau DA, Neiditch MB. (2011) An atypical Phr peptide regulates the developmental switch protein RapH. J Bacteriol. 193(22):6197-206.
- Sambanthamoorthy K, Gokhale AA, Lao W, Parashar V, Neiditch MB, Semmelhack MF, Lee I, Waters CM. (2011) Identification of a novel benzimidazole that inhibits bacterial biofilm formation in a broad-spectrum manner. Antimicrob Agents Chemother. 55(9):4369-78.
- Parashar V, Mirouze N, Dubnau DA, Neiditch MB. (2011) Structural basis of response regulator dephosphorylation by Rap phosphatases. PLoS Biol. 8;9(2):e1000589. doi:10.1371/journal.pbio.1000589
- Parashar V, Capalash N, Sharma P. (2007) Demonstration of REBASE-assisted restriction mapping to determine the recognition site of unknown restriction endonucleases. Biochem Mol Biol Educ. 35(5):337-41.
- Parashar V, Capalash N, Xu SY, Sako Y, Sharma P. (2006) TspMI, a thermostable isoschizomer of XmaI (5'C/CCGGG3'): characterization and single molecule imaging with DNA. Appl Microbiol Biotechnol. 72(5):917-23.
- Sharma P, D'Souza DR, Bhandari D, Parashar V, Capalash N. (2003) Demonstration of the Principles of Restriction Endonuclease Cleavage Reactions Using Thermostable Bfl I from Anoxybacillus flavithermus. Biochem Mol Biol Educ. 31:392-96