Dr. Kasinathan (center, front) with Chandni Patel, Rutgers Student; Mohammad Fakhreldin Osman, GSBS Student; and Rajesh Kaswala, RSDM Student.
Dr. Chinnaswamy Kasinathan is an Associate Professor in the Department
of Oral Biology at the University of Medicine and Dentistry of New Jersey.
He received his Ph.D. at the Postgraduate Institute of Medical Education
and Research in Chandigarh, India in 1984. He received postdoctoral
training in the Department of Physiology and Biophysics at Mount Sinai
School of Medicine New York, N. Y. before joining Department of Oral
Biology at Rutgers School of Dental Medicine in 1988.
His overall research is in studying post-translational modifications of proteins. Several post-translational modifications responsible for the processing of proteins have been well characterized in endoplasmic reticulum and in Golgi. But the tyrosine protein sulfation involving the transfer of sulfate from 3' phosphoadenosine 5' phosphosulfate to the hydroxyl group of tyrosine in protein has gained very little attention. The effects of tyrosine sulfaction on the secretion and biological activities of salivary proteins are being investigated. Additional research in his laboratory investigates the biochemical mechanism leading to alcoholism. Alcohol induced secretion of proteins has been well documented; however, the basic biochemical events which trigger this process are still unknown. Currently, his attention is directed in developing a sustained injectable drug for the treatment of narcotic drug addiction using the "Gel Depo" system, which can eliminate current limitations. Gel Depot is a novel, non-toxic, poly(ethylene glycol) based hydrogel system that is injected subcutaneously. This is in sharp contrast to other products under development based on irritating poly(lactic acid) and involves painful intra-muscular injections. We contend that use of naltrexone or methadone based Gel Depot can eliminate current limitation such as patient compliance since "Gel Depot" provides minimal burst effects, reduced potential for abuse.
Vaidyanathan, J., Kasinathan, C., and Vaidyanathan, T.K. Biometric
recognition and immunochemical assay of ligand binding to collagen. J.
Adhesive Dentistry. 5:7-17, 2003.
Kasinathan, C., Vrana, K., Beretta, L., Thomas, P., Gooch, R., Worst, T., Walker; S. Xu, A. Pierre, P., Green, H., Grant, K., and Manowitz, P. The future of proteomics in the study of alcoholism. Alcoholism: Clinical and Experimental Research. 28:228-232, 2004.
Kasinathan, C., Ramaprasad, P and Sundaram, P. Indentification and characterization of tyrosylprotein sulfotransferase from human saliva. Int. J. Biol. Sci. 1:141-145, 2005.
Kasinathan, C., Jean, S., and Manowitz, P. Tyrosine sulfation of arylsulfatase A and its peptide. Protein and Peptide Letters 13:357-361, 2006.
Kasinathan, C., Jean, S., and Manowitz, P. Tyrosine sulfation of arylsulfatase A and its peptide. Protein and Peptide Letters. 13:357-361, 2006.
Gostanian, H., Shey, Z., Kasinathan, C., Caceda, J., and Janal, M. An In Vitro Evaluation of the Effect of Sealant Characteristics on Laser fluorescence for Caries Detection. Pediatric Dentistry 28: 445-450, 2006
Kasinathan, C., Gandhi, N., Ramaprasad, P., Sundaram, P and Ramasubbu, N. Tyrosine Sulfation of Statherin. Int J Biol Sci. 3:237-241, 2007.
Sundaram, R.K., Kasinathan, C., Stein, S and Sundaram, P. Detoxification
Depot for ?-amyloid Peptides. Curr. Alzh. Res, 5, 26-32, 2008.
Ragunath, C., Manuel, S.G., Venkataraman, V., Sait, H.B., Kasinathan, C and Ramasubbu N. Probing the Role of Aromatic Residues at the Secondary Saccharide-Binding Sites of Human Salivary alpha-Amylase in Substrate Hydrolysis and Bacterial Binding. J. Mol Biol. 384(5):1232-1248, 2008.
Ragunath, C., Manuel, S.G.A., Kasinathan, C and Ramasubbu, N. Structure-function relationships in human alpha-amylase: Role of aromatic residues at the secondary binding sites. Biologia. 63(6) 1028-1034, 2008.
Sundaram, R.K., Kasinathan, C., Stein, S and Sundaram, P. Novel Detox Gel Depot Sequesters ?-Amyloid Peptides in a Mouse Model of Alzheimer's Disease. Int J Pept Res Ther. DOI 10.1007/s10989-011-9283-7.
Farooq M, Kaswala R.H, Kleiman N.J, Kasinathan C, Frederikse P.H. GluA2 AMPA glutamate receptor subunit exhibits codon 607 Q/R RNA editing in the lens Biochem Biophys Res Commun. 2012 Jan 10.
Monday, June 5, 2006