Center for Oral Infectious Diseases
Daniel E Kadouri, M.Sc, Ph.D.
Daniel Kadouri received a Bachelor of Science degree in Biology and Agriculture from the Hebrew University of Jerusalem in 1996, a Master of Science degree in Virology in 1998 and a Ph.D. in Microbiology from the same institution in 2003. He received his postdoctoral training in the Department of Microbiology and Immunology at Dartmouth Medical School, Hanover, N.H. Daniel joined the Department of Oral Biology at Rutgers School of Dental Medicine in 2006.
Kadouri's lab focuses on the interaction of biofilms and predatory prokaryotes. Most bacteria found in natural or industrial settings persist in complex microbial communities attached to surfaces or associated with interfaces (biofilms). Recently, there has been a renewed interest in the use of biological control agents against biofilms. In my lab we are using bacteria from the genera Bdellovibrio and Micavibrio in order to reduce biofilms with the long term goal of harnessing the potential of these organisms in controlling biofilms both in medical and industrial settings, developing novel biological control strategies, and employing these biological systems as means of enhancing classical biofilm control techniques. We are currently developing new methods that will allow us to understand the biology of Micavibrio spp. and Bdellovibrio spp. and identify mechanisms which are involved in predator-prey interactions. In another study we are focusing on isolating novel antimicrobial and biofilm degrading compounds from bacteria and biofilms.
Kadouri Lab current research projects
Our research is focused on the following projects:
(A) Predatory Prokaryotes:
- Understanding the biology of Micavibrio spp. and Bdellovibrio spp. using genetic and biochemical approach.
- Identifying mechanisms involved in predator-prey interactions and studying their association with surface attached bacteria.
- Understanding the role of biofilms in Bdellovibrio biology.
- Investigating the ?crosstalk? between the predator and its microbial host.
- Using predatory prokaryotes to control drug resistant bacteria and microbial biofilms associated with infections.
- Enhancing predatory prokaryotes ability to reduce biofilms.
- Isolating novel antimicrobial compounds from Bdellovibrio spp and Micavibrio spp.
(B) Isolating novel antimicrobial and biofilm degrading
compounds from bacteria and biofilms.
(C) Use of microbial derived compounds for postoperative pain relief.
(D) Biofilm formation and cell-to-cell association of oral pathogens.
Kadouri, D., E. Jurkevitch, Y. Okon, and S. Castro-Sowinski. 2005. Ecological and agricultural significance of bacterial polyhydroxyalkanoates. Crit Rev Microbiol 31:55-67.
Kadouri, D., and G. A. O'Toole. 2005. Susceptibility of biofilms to Bdellovibrio bacteriovorus attack. Appl Environ Microbiol 71:4044-4051.
Merritt, J. H., D. E. Kadouri, and G. A. O'Toole. 2005. Growing and analyzing static biofilms. Curr Protoc Microbiol Chapter 1:Unit 1B 1.
Kadouri, D., N. C. Venzon, and G. A. O'Toole. 2007. Vulnerability of pathogenic biofilms to Micavibrio aeruginosavorus. Appl Environ Microbiol 73:605-614.
Medina, A. A., R. M. Shanks, and D. E. Kadouri. 2008. Development of a novel system for isolating genes involved in predator-prey interactions using host independent derivatives of Bdellovibrio bacteriovorus 109J. BMC Microbiol 8:33.
Dashiff, A., and D. E. Kadouri. 2009. A New Method for Isolating Host-Independent Variants of Bdellovibrio bacteriovorus Using E. coli Auxotrophs. Open Microbiol J 3:87-91.
Medina, A. A., and D. E. Kadouri. 2009. Biofilm formation of Bdellovibrio bacteriovorus host-independent derivatives. Res Microbiol 160:224-231.
Shanks, R. M., D. E. Kadouri, D. P. MacEachran, and G. A. O'Toole. 2009. New yeast recombineering tools for bacteria. Plasmid 62:88-97.
Bendaoud, M., E. Vinogradov, N. V. Balashova, D. E. Kadouri, S. C. Kachlany, and J. B. Kaplan. 2011. Broad Spectrum Biofilm Inhibition by Kingella kingae Exopolysaccharide. J Bacteriology. 193:3879-3886.
Craigen, B., A. Dashiff, and D. E. Kadouri. 2011. The use of alpha-Amylase to inhibit and remove Staphylococcus aureus biofilms. Research in Microbiology, Open Microbiol J. 5:21-31.
Dashiff, A., R. A. Junka, M. Libera, and D. E. Kadouri. 2011. Predation of human pathogens by the predatory bacteria Micavibrio aeruginosavorus and Bdellovibrio bacteriovorus. J Appl Microbiol 110:431-444.
Dashiff, A., and D. E. Kadouri. 2011. Predation of oral pathogens by Bdellovibrio bacteriovorus 109J. Mol Oral Microbiol 26:19-34.
Dashiff, A., T. G. Keeling, and D. E. Kadouri. 2011. Inhibition of predation by Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus via host cell metabolic activity in the presence of carbohydrates. Appl Environ Microbiol 77:2224-2231.
Wang, Z., D. E. Kadouri, and M. Wu. 2011. Genomic Insights into An Obligate Epibiotic Bacterial Predator: Micavibrio aeruginosavorus ARL-13. BMC Genomics. 12:453-459.
Shanks, R. M., A. Dashiff, J. S. Alster, and D. E. Kadouri. 2012 Isolation and Identification of a bacteriocin with antibacterial and antibiofilm activity from Citrobacter freundii. ARCH Microbiology (In press).
Friday, November 17, 2006