Center for Oral Infectious Diseases

Daniel H. Fine, DMD

Daniel H. Fine, DMD
Phone: 973-972-3728
Fax: 973-972-0045

Dr. Daniel H. Fine is currently a Professor and Chairman of the Department of Oral Biology and Director of the Center for Oral Infectious Diseases. He received his Bachelor of Science degree from Queens College, his DMD from the University of Pennsylvania in 1965 and his Certificate in Periodontology in 1967 from New York University. He served on the dental faculties of the University of Pittsburgh (1967-1970) and the Columbia University School of Dental and Oral Surgery (1971-1994) before coming to the Rutgers School of Dental Medicine in mid-1994 as Director of the Dental Research Center.

Dr. Fine's research focuses on host/parasite interactions in periodontal disease with a special emphasis on molecular genetics related to virulence of actinobacillus actinomycetemcomitans. His group also investigates genetic susceptibility of individuals to juvenile periodontitis. In addition, Dr. Fine's laboratory participates in studies of biofilm development and methods that would interfere with development.

Recent Publications

Karched M., Furgang, D., Sawalha, N. Fine, D.H. Rapid identification of oral isolates of Aggregatibacter actinomycetemcomitans obtained from humans and primates by an ultrafast super convection based polymerase chain reaction. Journal of Microbiological Methods, 2012, In press.

Schreiner, H., Markowitz, K., Miryalkar, M., Moore, D., Diehl, S., Fine, D.H. Aggregatibacter Actinomycetemcomitans - Induced Bone Loss and Antibody Response in Three Rat Strains. J. Periodontol. 82(1):142.50 Jan 2011.

Maribasappa, K., Furgang, D., Planet, P.J., DeSalle, R., Fine, D.H. Genome Sequence of Aggregatibacter actinomycetemcomitans RHAA1, Isolated from a rhesus macaque, an old world primate. Journal of Bacteriology. 1275-1276. 2011.

Fine, D.H., Furgang, D., McKiernan, M., Tereski-Bischio, D., Ricci, D., Zhang, P., Araujo, M.W. An investigation of the effect of an essential oil mouthrinse on induced bacteraemia: a pilot study. J Clin Periodontol. 37(9): 840-7, Sep. 2010.

Fine, D.H., Markowitz, K., Furgang, D., Velliyagounder, K. Aggregatibacter actinomycetemcomitans as an early colonizer of oral tissues: Epithelium as a reservoir J Clin Microbiol. Vol. 48 (12): 4464-4473.  Sep. 2010.

Li, Y., Messina, C., Bendaoud, M., Fine, D.H., Schreiner, H., Tsiagbe, V.K. Adaptive immune response in osteoclastic bone resorption induced by orally administered Aggregatibacter actinomycetemcomitans in a rat model of periodontal disease. Mol Oral Microbiol. 25 (4): 275-92, Aug. 2010.

Fine, D.H., Kaplan, J.B., Furgang, D., Karched, M., Velliyagounder, K., Yu, E. Mapping the epithelial cell binding domain of the Aggregatibacter actinomycetemcomitans autotransporter adhesin Aae. Microbiology. 156, 3412-3420. Aug. 2010.

Sreenivasan, P.K., Furgang, D., Markowitz, K., McKiernan, M., Bereski, Tischio, D., Devizio, W., Fine, D.
Clinical anti-microbial efficacy of a new zinc citrate dentifrice. Clin Oral Inve13:195-202, 2009

Fine, D.H., Markowitz, K., Furgang, D., Fairlie, K., Ferrandiz, J., Nasri, C., Mckiernan, M., Donnely, R., Gunsolley, J. Macrophage Inflamatory protein- 1: A Salivary Biomarker of Bone Loss in a Longitudinal Cohort Study of Children at Risk for Aggressive Periodontal Disease Periodontol, Vol. 80, Number 1, pg. 106-113, January 2009.

Fine, D.H. Of mice and men: animal models of human periodontal disease. Journal of Clinical Peridontology, Vol. 36: 913-914, 2009.

Bonaventura, M. P., DeSalle, R., Pop, M., Nagarajan, N., Firgurski, D.H., Fine, D.H., Kaplan, J.B., Planet, P.J. Complete Genome Sequence of Aggregatibacter (Haemophilus) aphrophilus NJ8700. Journal of Bacteriology, p. 4693.4694, July 2009.

Fine, D.H., Markowitz, K., Furgang, D., Fairlie, K., Ferrandiz, J., Nasri, C., Mckiernan, M., Gunsolley, J. Aggregatibacter actinomycetemcomitans and its relationship to initiation of Localized Aggressive Periodontitis: Longitudinal cohort study of initially healthy adolescents. Journal of Clinical Microbiology. Vol. 45(12). 3859-3869. 2007.

Fine, DH., Velliyagounder, K., Furgang D., Kaplan, JB. The Actinobacillus actinomycetemcomitans Autotransporter Adhesin Aae Exhibits Specificity for Buccal Epithelial Cells from Humans and Old World Primates. Infection and Immunity. p. 1947-1953, 2005.

Kaplan, JB., Meyenhoff, MF., Fine, DH. Biofilm growth and detachment of Actinobacillus actinomycetemcomitans. Journal of Bacteriology. Vol185, 1399-1404, 2003.

Kaplan, JB., Meyenoff, MF., and Fine, DH. Biofilm growth and detachment of Actinobacillus Actinomycetemcomitans. Journal of Bacteriology. Vol. 185, No. 4, 1399-1404, 2003.

Schreiner, Helen, C., Sinatra, Kathy, Kaplan, Jeffrey, B., Furgang, David, Kachlany, Scott, C., Planet, Paul, J., Perez, Brenda, A., Figurski, David, H., Fine Daniel, H. Tight adherence genes of Actinobacillus actinomycetemcomitans are required for virulence in a rat model. PNAS. Vol. 100, No. 12 7295-7300. 2003.

Kablian Velliyagounder, Jeffrey B. Kaplan, David Furgang, Diana Legarda, Gill Diamond, Ruth E. Parkin, and Daniel H. Fine. One of Two Human Lactoferrin Variants Exhibits Increased Activation Activities and Is Associated with Localized Juvenile Periodontitis. Infection and Immunity. Nov. 2003, p. 6141-6147 2003.

Kaplan, JB., and Fine, DH. Biofilm dispersal of Neiserria subflava and other phylogenetically diverse oral bacteria. Applied Environment Microbiol. Vol. 68, 4943-4950, 2002.

Tuesday, June 6, 2006