Center for Oral Infectious Diseases
Amalia Slomiany, Ph.D.
Dr. Amalia Slomiany is a Professor in the Department of Oral Biology. She received her Ph.D. at New York Medical College, NYC, Department of Biochemistry in 1973.
Dr. Slomiany's basic research on cell biology is based on the theory that agents available in the local milieu can activate homeostasis, oncogenic or microbe-induced cells responses. The role of epigenetic factors on cell homeostatic renewal, biomembrane synthesis and secretory activity (exocytosis) is carried out on epithelial cells of gastric and oral mucosal tissue. The control of the epithelial environment is investigated in complex environments that include cell membrane protein and secretory glycoprotein (mucin). Lipopolysaccharide (LPS) mimicry of mucin carbohydrate structures and competition for interaction with mucin binding protein of the apical epithelial membrane is also investigated. The LPS-induced changes in epithelial cell signaling pathways and the strategies to prevent these events are also studied. The ultimate goal of these investigations is to determine the optimal epithelial environment with capacity to prevent microbial infection, to signal epithelial self-renewal, in order to restore damaged epithelial tissue in ulcerative erosions.
Slomiany, A., Grabska, M., and Slomiany, BL. Essential components of antimicrobial epithelial barrier: Specific interaction of mucin with an integral apical membrane protein of gastric mucosa. Molecular Medicine - Vol. 7, pgs. 1-10, 2001
Slomiany, BL., and Slomiany, A. Disruption in gastric mucin synthesis by Helicobacter pylori lipopolysaccharide involves ERK and p38 MAP kinase participation. Biochemical and Biophysical Research Communications - Vol. 294, pgs. 220-224, 2002
Slomiany, A., Nishikawa, H., and Slomiany BL. Screening and modulation of extracelluar signals by mucous barrier. Serum glycosylophosphatidylinositol phospholipase D (GPI-PLD) releases protective mucous barrier from oral mucosa. Journal of Physiology and Pharmacology - Vol. 53, pgs. 21-38, 2002
Slomiany, A., Slomiany, BL. Lipidomic processes in homeostatic and LPS-modified cell renewal cycle. Role of phosphatidylinositol 3-kinase pathway in biomembrane synthesis and restitution of apical epithelial membrane. J Physiol Pharmacol 2003; 54: 533-551.
Slomiany, BL., Slomiany, A. Biphasic role of platelet-activating factor in oral mucosal ulcer healing. IUBMB Life 2003; 55: 483-490.
Slomiany, BL., Slomiany, A. Role of epidermal growth factor receptor transactivation in PPARy- dependent suppression of Helicobacter pylori interference with gastric mucin synthesis. Inflammopharmacol 2004; 12: 177-188.
Slomiany, BL., Slomiany, A. Salivary phospholipid secretion in response to B-adrenergic stimulation is medicated by Src kinase-dependent epidermal growth factor transactivation. Biochem Biophys Res Commun. 2004; 318: 247-252.
Slomiany, A., Sano, S., Grabska, M., Yamaki, K. and Slomiany, BL. Mucosal cell Homeostatic physiome. Critical role of ER-initiated membranes restitution in the fidelity of cell function renewal. J. Physiol. Pharmacol. 2004; 55, 837-860.
Tuesday, April 12, 2005